Michal Schwartz (born 1 January 1950) is a professor of Neuroimmunology at the Weizmann Institute of Science and is internationally acclaimed as a path-breaking scientist in the study of Neuro-immunology, introducing the dialogue between the immune system and the brain as novel and pivotal player in life-long brain function and repair. Prof. Michal Schwartz groundbreaking discovery has revolutionized the field of neurodegenerative diseases, and led to a transformation in searching treatments for Neurodegenerative diseases, Her immunotherapeutic approach to treat of harnessing the immune system to help brain to treat terminal neurodegenerative brain diseases such as Alzheimer Disease and Dementia, is currently in expedite process of development. In her pioneering studies, she has shown, against prevailing wisdom at the time, that the immune system supports a health brain function and is vital for healing and protecting the brain in case of injury or disease. Prof. Schwartz research has not only changed the accepted scientific dogma, but laid the foundation worldwide for developing new research and treatment approaches in the field of brain disease and neurodegenerative conditions, particularly Alzheimer Disease and Dementia.

Prof. Moussa Youdim founded the Department of Pharmacology at the Rappaport Faculty of Medicine at the Technion. He chaired the department from 1977 to 1994 and was the Finkelstein Professor of Life Sciences. He has held numerous prestigious academic positions in universities worldwide. Moussa is the Founder, Chief Scientific Officer, and President of Youdim Pharmaceuticals, the Scientific organizer of Cardiamit Ltd., the Scientific Founder of Avraham Pharmaceuticals, and the Chief Scientific Officer of Abital Pharma Pipeline Ltd. He is internationally renowned for his research on monoamine oxidases, brain iron metabolism, Parkinson disease, Alzheimer disease, and amyotrophic lateral sclerosis. He has worked on drug development for these disorders and has established the importance of monoamine oxidase and brain iron metabolism for brain function and dysfunction. His research at Oxford University led to the discovery of the first monoamine oxidase B inhibitor, l-deprenyl selegiline, as an anti-Parkinson drug and he developed the concept of neuroprotection. At the Technion, he developed the second generation of neuroprotective monoamine oxidase B inhibitor anti-Parkinson drug, Rasagiline Azilect with Teva Pharmaceuticals. He developed the first multifunctional neuroprotective anti-Alzheimer drug, currently designated Ladostigil , and novel multi-target neurorestorative M30 iron chelator and Exegiline series, which are under development for Parkinson and Alzheimer diseases at Youdim Pharmaceuticals. He holds over 100 drug patents, has published more than 900 scientific articles, edited 45 books, and sat on the editorial boards of 43 international scientific journals. In addition, he has received some 40 major national and international prizes and awards including honors from Iran, Israel, the United States, England, Germany, Denmark, Holland, and Switzerland. He has also received two honorary doctorate degrees from Semmelweis University, Hungry, and the University of Pisa, Italy. He is an elected member of Leopoldina, the German Academy of Sciences, and the Hungarian Academy of Sciences. He has received over 40 honors, awards, and prizes nationally and internationally. In 2010 he was awarded the European College of Neuropsychopharmacology Lifetime Achievement Award and the Israeli EMET prize for Brain Research. He has also received the International College of Neuropsychopharmacology Pioneering Award, the Arvid Carlsson Medal, and the Catecholamine Pioneering Award from the National Institutes of Health. He was elected an Honorary Member of the Israel Society for Neuroscience for his fundamental contributions to the field. In 2022 he received the Israel Prize in Life Sciences.

Susana J. Pasquare is full professor of Biological Chemistry II at Universidad Nacional del Sur UNS Argentina, professor in charge of two postgraduate courses at UNS, and 3) collaborating professor of the Diploma Course in Medicinal Cannabis at Universidad Nacional Arturo Jaureche UNAJ and a postgraduate course at the School of Medical Sciences of Universidad Nacional de La Plata. She is a researcher at Instituto de Investigations Bioquimicas de Bahia Blanca INIBIBB, an Argentinean research center depending on CONICET and UNS, where she is Director of the Laboratory of Cannabin ology and is also in charge of CONICET High Technological Level Service Determination of the composition of plant origin products and their derivatives. Her field of research on endocannabinoids was initiated in 2007 with a study on the endocannabinoid system ECS in physiological neurodegenerative processes in an in vivo normal aging model. She further studied ECS in pathological neurodegenerative processes in in vitro models of induced neuronal injury. A new line of research was also initiated in her lab for the study of ECS regulation in the visual process. At present her studies are centered on elucidating whether ECS is altered in the injury induced by or by high light intensity by exploring its regulation through the action of neuromodulators and complete extracts derived either from Cannabis sp. plant with different Phyto cannabinoid composition or from its pure active principles. She was awarded a Postdoctoral Research Fellowship granted by the Ministry of Education, Science and Technology Argentina Carolina Foundation Spain for a stay at Instituto Ramon Cajal, Madrid, Spain an Erasmus Teaching Staff Mobility Fellowship for a stay at University of Deist Spain and a prize and grant from Florencio Fiorina Foundation and the National Academy of Medicine Argentina to conduct research in Biomedical Sciences. She has extensive experience in human resource training, has been awarded several grants, is author of 44 publications in high impact journals, has been invited to lecture at several international and national scientific meetings, being in some of them member of their Scientific Committee and has been in charge of several evaluation commitments.

Jennifer Pocock is a full professor of Cellular Neuroscience at University College London, Queen Square Institute of Neurology, Department of Neuroinflammation, where, since 1996, and is head of the Cellular Signalling Laboratory. Her lab focus has been on understanding the role of microglia in neurodegeneration. In particular, she has a deep interest in the role of these innate immune cells in the pathology underlying Alzheimers disease and multiple sclerosis. She has used in vitro techniques together with cellular, molecular, and biochemical methodologies to understand how microglia are protective as well as pathological. She has, with her research team, published over 90 papers on this topic successfully supervised over 20 Ph.D. students, many of whom have gone on to successful careers in the microglial field, and have received funding from UKRI including MRC, BBSRC, as well as the Wellcome Trust, EU Horizon 2020 (IMI), Alzheimers Research Trust, the Rosetrees Trust, Brain Research Trust, Aims2Cure, as well as funding and collaborations with industry. Her recent approach has been to understand the role of AD risk factors and to investigate how the gene variants linked to these influence microglial behavior, using iPSC-derived patient microglia to study the role of TREM2 and CD33.

Bin Zhang, Professor, and Director Dr. Zhang is currently the Willard T.C. Johnson Research Professor of Neurogenetics at the Department of Genetics and Genomic Sciences and the Director of the Mount Sinai Center for Transformative Disease Modeling, at the Icahn School of Medicine at Mount Sinai, New York, USA. His expertise lies in bioinformatics, systems biology, and artificial intelligence with applications to disease modeling and drug discovery. His team has developed a series of influential gene network inference algorithms which have been extensively used for the identification of novel pathways and key targets, as well as the development of drugs for complex human diseases such as cancer, atherosclerosis, Alzheimers, Parkinsons, depression, obesity, diabetes, and infectious diseases. His current research is focused on developing mechanistic molecular models of complex diseases and novel therapeutics for treating such diseases using artificial intelligence and deep machine learning approaches. His work on predicting genetic interactions was identified by Nature Biotechnology as one of the breakthroughs in the field of computational biology in 2010. His research that uncovered an immune/microglia gene network causally linked to Alzheimers disease (AD) was published in Cell and selected by the Journal of Alzheimers Disease as one of the top 50 most influential papers on AD published from 2013 to 2017. His recent work on the multiscale network modeling of AD systematically uncovered multiple neuronal gene subnetworks as the most dysregulated in AD and successfully validated the functional relevance of a top driver gene in different model systems. His latest research systematically uncovered and characterized five molecular subtypes in AD. As a prolific researcher, he has published over 220 papers including a number of high-profile papers in the top scientific journals.

Prof. dr. Harry W.M. Steinbusch is appointed as Emeritus Professor in Cellular and Translational Neuroscience at the University of Maastricht (UM) in the Netherlands. His main research focus is on the neuroanatomical aspects of development and aging in rodent and post-mortem human brain. The general working hypothesis is that pre/peri or postnatal stress could lead to depression, which could alone be an early initiator of further progression of neurodegeneration like AD. The focus is on the role of the Brainstem in the early pathophysiology of AD and the relation between depression and AD using a broad range of techniques, i.e., molecular neurobiology, quantitative neuromorphology, animal behaviour and epigenetics. Currently, he is Coordinator of the China Scholarship Council PhD Program at UM comprising close to 324 PhD students and Strategic Advisor for China policies at Ruhr University Bochum, Germany. He is Co-Chair of the IBRO-ECC Mentorship Initiative to train PhD students and postdocs as an international group to write commissioned review articles. He is Founding and Current Editor-in-Chief of the Journal of Chemical Neuroanatomy, current SCI: 3.1, by Elsevier, since 1984. He is co-organizer of the Bright Focus Foundation initiated Alzheimer Fast Track Annual 4 days workshop for young career scientists for 23 years. He has thus far guided 98 Ph.D. students and published 505 papers. He has been twice coordinating a Marie Curie Early-Stage Training site and coordinator of an Erasmus Mundus + program between 4 European and 3 Japanese Universities. His current Hirsch factor is 103, citations without self-citations 39,840, from 2018: 9,558 and M-factor is 2.3. For international achievements, he received the title of Knight in the Order of the Dutch Lion, 2018. Lifetime Achievement Awards were received from the Italian Neuroscience Society, in 2017, the South Korean Neuroscience Society, 2018 and the International Society for Serotonin Research, 2018.

Dr. Mutoh got his MD and Ph.D. degree from Nagoya University School of Medicine, Nagoya, Japan. He was appointed as an assistant Prof. at Fukui Medical School and moved to NIH, NICHD, USA as a visiting fellow from 1987-1990. He was promoted to full professor and Chairman at the Department of Neurology, Fujita Health University School of Medicine, Japan in 2005. His current interest is neuroglycobiology, immunology, protein-lipid interaction, and signal transduction of neurodegenerative and neuroimmunological diseases. He has been acting as a fellow of American Academy of Neurology and being an editorial board member of Front Cell Neurosci Associate Editor, Front Biosci Managing Editor, AIMS Medical Science Section Editor in Chief, and so on. He has also served as an external review board of grants of Italian Ministry of Science and Technologyfor more than 20 years and as a visiting Prof. at the Dept. of Neurology, Juntendo University School of Medicine, Tokyo, and at the 2nd Dept. of Internal Medicine, University of Fukui School of Medicine, Fukui, Japan.

A neurologist with a special focus on the contribution of immune cells in the development and progression of neurological disorders such as Multiple Sclerosis and Alzheimers Disease, and over 10 years of experience in preclinical models. Tommaso received his medical degree from the University of Genoa and completed his residency in neurology at San Raffaele Hospital in Milan. He went on to enroll in a Ph.D. in neuroimmunology at the Weizmann Institute of Science, where he developed a keen interest in the relationship between the immune system and the brain. His research has focused on understanding the underlying mechanisms by which immune cells contribute to the pathology of neurological disorders, as well as developing novel therapeutic strategies to target the immune system.

Dr. Howard E. Gendelman is the Margaret R. Larson Professor of Internal Medicine and Infectious Diseases, chairman of the Department of Pharmacology and Experimental Neuroscience and director of the Center for Neurodegenerative Disorders at the University of Nebraska Medical Center. Dr. Gendelman is credited with unraveling how functional alterations in brain immunity induce metabolic changes and ultimately lead to neural cell damage across a broad range of infectious, metabolic, and neurodegenerative disorders. These discoveries have had broad implications on developmental therapeutics aimed at preventing, slowing, or reversing neural maladies. He is also credited with demonstrating that AIDS dementia is a reversible metabolic encephalopathy. His work has led to novel immunotherapy strategies for Parkinson's disease that have been successfully tested in early clinical trials as a result of translational investigations.

Dr. Kazuhide Inoue is the University Professor, The Institute for Advanced Studyof Kyushu University. Professor Inoue has published hundreds of papers on the subject of the function of purinergic receptors in CNS, especially in pain signaling. He found that P2X4 receptors in spinal microglia has important role in the expression of neuropathic pain that is often refractory to treatment with NSAIDs and opioids. In 1975, he graduated School of Pharmaceutical Sciences, Kyushu University, and 1978 he started to research at National Institute of Health Sciences, Japan. He studied abroad in NIH, USA as a visiting fellow from 1985 until 1987, and in University College London as an honorary research fellow from 1991 till 1992. In 2000, he became a professor of Graduate School of Pharmaceutical Sciences, Kyushu University. From 2014 till 2020, he worked as the Executive Vice-President of Kyushu University.He was awarded Science Technology Award from the Minister of Education, Culture, Sports, Science and Technology-Japan in 2007, the 3rd Setsuro Ebashi Prize of The Japanese Pharmacological Society in 2010, Medal from His Majesty the Spanish Emperor as an honor of Royal Academy of Pharmacy in 2010, The Pharmaceutical Society of Japan Award in 2013, and Medal with Purple Ribbon from His Majesty the Emperor in 2014.

Michel Barrot is a Research Director at CNRS and Director of the Institute des Neurosciences Cellulaires & Integrative INCI in Strasbourg, France. He did his Ph.D. training at INSERM and Bordeaux University in France, working on dopamine systems. After postdoctoral training in the Molecular Psychiatry department at Yale University, he was appointed Assistant Professor in the Psychiatry department at the UT Southwestern Medical Center at Dallas and then recruited for a tenure researcher position by the CNRS in France in 2003. Within INCI, he directs research projects on the treatment of, and the relation between, chronic pain and mood disorders and on the neuroanatomy and physiology of dopamine systems.

Nicolas SERGEANT is an Inserm Research Director from the natural history of Alzheimers disease, the development of cell models for the screening of drugs against Alzheimers disease and Tauopathies, also thanks to a long-term collaboration with the organic chemistry laboratory of Pr. Patricia Melnyk has identify small drugs molecules that are active towards both lesional processes of Alzheimers disease. One of these, is currently in clinical phase II by Alzprotect Biotech Company. He is also delighted to identify, assess, and validate biomarkers to assess neurodegenerative processes in neurological disorders and also develop gene therapy using a molecular decoy strategy.

Dr. Nagy has worked on the mechanisms involved in peripheral and spinal neuronal processing for 30 years. He has been particularly interested in the neurochemistry, physiology and pharmacology of nociceptive processing. He has been working at Imperial College London since 1998, where he is one of the leading basic pain scientists. His pioneering work on heat transduction mechanisms and interactions between the endo vanilloid and endo cannabinoid systems has significantly contributed to the knowledge, which underlies the recent development of novel pharmacological approaches for pain control. He uses a broad repertoire of techniques including molecular, biochemical, and electrophysiological, pharmacological, morphological and behavioral approaches. Dr Nagy is the principal author of many highly-cited, seminal publications in peer-reviewed journals and books. He is a regularly invited speaker, key-note presenter and session organizer at various international conferences. As a principal investigator, Dr Nagy leads the work of a group of undergraduate and postgraduate students, as well as postdoctoral scientists. He has extensive collaboration with several academic and industrial scientists both within the UK and overseas.

Sergey Suchkov graduated from Astrakhan State Medical University and was awarded with MD, then in 1985 maintained his Ph.D. at the I.M. Sechenov Moscow Medical Academy and in 2001, maintained his Doctorship Degree at the Nat Inst of Immunology, Russia.From 1987 through 1989, he was a senior Researcher, KoltzovInst of Developmental Biology. From 1989 through 1995, he was a Head of the Lab of Clinical Immunology, at Helmholtz Eye Research Institute in Moscow. From 1995 through 2004, a Chair of the Dept for Clinical Immunology, Moscow Clinical Research Institute (MONIKI.Dr. Suchkov has been trained at NIH Wills Eye Hospital, PA, USA Univ of Florida in Gainesville UCSF, S-F, CA, USAJohns Hopkins University, Baltimore, MD, USA. He was an Exe Secretary-in-Chief of the Editorial Board, Biomedical Science, an international journal published jointly by the USSR Academy of Sciences and the Royal Society of Chemistry, UK. At present, Dr Sergey Suchkov is a Chair, Dept for Personalized Medicine, Precision Nutriciology and Biodesign of the Institute for Biotech &Global Health of RosBioTech, and Professor of the Dept for Clinical Allergology& Immunology of A.I. Evdokimov MGMSU, Russia. He is a member of the: New York Academy of Sciences, USA American Chemical Society (ACS), USA; American Heart Association (AHA), USA; EPMA (European Association for Predictive, Preventive and Personalized Medicine), Brussels, EU; ARVO (American Association for Research in Vision and Ophthalmology); ISER (International Society for Eye Research)PMC (Personalized Medicine Coalition), Washington, USA.

Jose Luis Gomez Ariza is a full professor of Analytical Chemistry and Director of the Research Center for Natural Resources Health and the Environment of the University of Huelva (Spain). Member of the Spanish Society for Analytical Chemistry (SEQA) and the Academy of Sciences, Arts and Letters of Huelva. In 2003 received the Andalusia Research Award and the Huelva Industry Excellence Award. In 2018 he received the Research Award from Faculty of Chemistry of Huelva University and in 2022 the Gold medal of Huelva University and the Magister award from the Higher Technical School of Engineers of the University of Huelva for his teaching and research career His research interests focus on the study of new analytical approaches to characterize metalloproteins and other metal and non-metal-containing biomolecules using multidimensional analytical approaches (metallomics) and the combination with other omics such as metabolomics, proteomics, and transcriptomics, with the purpose to study the environment action on aging as well as neurodegenerative diseases, especially Alzheimer. He is the author or co-author of over 300 scientific publications, several books, and holds several patents. Over 35 students have received doctorates under his direction; many others have received M.S. degrees, and scores of undergraduates and visiting scientists have performed research in his laboratory. J.L. Gomez-Ariza is a member of the Spanish Society for Analytical Chemistry (SEQA), Royal Society of Chemistry, American Chemical Society and American Society for Biochemistry and Molecular Biology. He was president of Speciation Group of SEQA and the Andalusia Group of the Spanish Society for Analytical Chemistry (GRASEQA). At present, he is a member of the advisory board of the journal METALLOMICS (RSC) and co-editor of Current Alzheimer Research.

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Krueger received his Bachelor of Science from the University of Wisconsin, his doctorate in physiology from the University of Pennsylvania, and his Doctorem Medicinae Honoris Causa from the University of Szeged. From 1974-78 he served as a research fellow and then an instructor in the Harvard Medical School Departments of Physiology and Biochemistry, and from 1978-81 he was a research associate in Physiology. In 1981, he joined the Chicago Medical School Department of Physiology and Biophysics. He was an associate and full professor from 1985-97 at the Department of Physiology and Biophysics at the University of Tennessee. He joined WSU in 1997, and in 2007 was named a WSU Regents Professor. In 2010, Krueger received designation as Eminent Professor, the highest award given to WSU faculty. In 2012, he was named the WSU Honors College Faculty Thesis Advisor of the Year and elected to the Washington State Academy of Sciences.

Juan Lerma is Vicepresident of the European Brain Council, Director of the Cajal International Neuroscience Center (CINC-CSIC) and Research Professor at CSIC. Professor Lerma is also Councilor of North American Society for Neuroscience (SfN) and Editor-in-chief of Neuroscience, the flagship journal of the International Brain Research Organization (IBRO) and one of the oldest publications in international neuroscience. He has been President of the Spanish Neuroscience Society (SENC) from 2011 to 2013; Chairman of the IBRO Pan-European Committee, 2013-16; and Secretary General of the Federation of European Neuroscience Societies (FENS), 2016-2018. He is a member of the European Academy; of the European Dana Alliance for the Brain (EDAB) and the European Molecular Biology Organization (EMBO).In 2016, Professor Lerma received the Gold Medal from the Institute of Neurosciences (CSIC-UMH) for his successful work as the head of the Institute.This recognition is in addition to other important national and international distinctions received throughout his research career. Research line:Director of the Synaptic Physiology group at the Institute of Neurosciences in Alicante, his line of research is related to the molecular bases of neuronal communication, specifically the mechanisms used by the neurotransmitter glutamate in synaptic transmission and brain plasticity, and its ability to trigger brain diseases when dysregulated. Lerma is one of the Spanish scientists whose work on the mechanisms that govern neuronal communication have had the greatest impact in the international level, and his research on neurotransmission processes broke new grounds in modern neuroscience.

Anju Vasudevan, PhD is an Associate Professor of Neuroscience, Director of the Angiogenesis & Brain Development Laboratory, and Chair/Scientific Director of the Department of Neurosciences at Huntington Medical Research Institutes (HMRI), Pasadena, California. Dr. Vasudevan received her PhD in Neuroscience from the University of Cologne, Germany, and completed her postdoctoral work at Massachusetts General Hospital and Harvard Medical School. From 2007-2020, Dr. Vasudevan was a faculty member in the Departments of Neurology and Psychiatry at Harvard Medical School. Dr. Vasudevan established the Angiogenesis and Brain Development Laboratory (ABDL) in 2011, at McLean Hospital, which pursues basic and translational research in neuroscience. The ABDL moved to HMRI in 2020, and is also known as the Neurovascular Research Program here. Dr. Vasudevan work on early embryogenesis of the forebrain vascular system, and diversity of endothelial cell populations, has opened an entirely new conceptual framework from which to view this critical component of brain development. Her work has brought forth the new perspective that blood vessel-related defects from the brain earliest developmental stages can contribute to psychiatric disease origin. It underscored the importance of non-neuronal signaling via forebrain endothelial cells that is of new significance for neuropsychiatric illness. In addition, Dr. Vasudevan research program is tapping into the potential of embryonic forebrain endothelial cells to prevent the origin of psychiatric symptoms, by rescuing vascular defects in the prenatal brain, or by developing vascular therapies for repair and regeneration in the adult brain. This work has implications for understanding, prevention, and treatment of a variety of nervous system disorders like schizophrenia, autism, epilepsy, developmental delays, anxiety, and depression. Dr. Vasudevan is the recipient of the NARSAD Young and Independent Investigator Awards, and awards from the National Institute of Neurological Disorders and Stroke, and from the National Institute of Mental Health.

Junghyup Suh, PhD is an Instructor in the Division of Depression and Anxiety Disorders at McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA. Dr. Suh received his PhD in Developmental Neurobiology from Rutgers, the State University of New Jersey, and Robert Wood Johnson Medical School, and completed her postdoctoral work in the laboratory of Dr. Susumu Tonegawa, a Nobel laureate, at the Picower Institute of Learning and Memory, Massachusetts Institute of Technology. In 2016, Dr. Suh joined at McLean Hospital as a faculty member to pursue translational research in neuroscience. His overarching research interest is to advance our understanding of the neural principles underlying cognition and behavior, with a major focus on how traumatic experiences impact on the brain's stress and reward circuitry and ultimately increase vulnerability to drug addiction. His education and training have included in-depth experience with molecular and genetic techniques, systems neuroscience, and behavioral phenotyping. Using the whole of his foundational knowledge and broad technical expertise, he is particularly interested in how exposure to stress and alcohol alter neuronal activity and functional connectivity in the corticolimbic system and lead to the development of alcohol dependence and addiction. In this context, he has been actively performing optogenetic manipulation of neuronal circuits and cellular-resolution fluorescent calcium imaging techniques in freely behaving mice that are subjected to an array of behavioral assays. His research has been funded by the National Institute of Alcohol Abuse and Alcoholism.

Brittany Needham studied bacterial cell wall modification in the laboratory of M. Stephen Trent at University of Texas at Austin before working as a postdoctoral scholar at Caltech in the laboratory of Sarkis Mazmanian. Her research interests focus on the gut microbiome, which harbors astonishing genetic diversity, with over 22 million genes sequenced from human gut microbial populations, and an immense pool of unique enzymes capable of producing and modifying a wide array of chemical structural groups. Influence of this dense community, with its dynamic metabolic activity and bidirectional flux of molecules between microbe and host, extends beyond the gut into the entire body, including the brain. In fact, integration of molecular inputs from within the gut can shape animal health and behavior, with recent examples showing that an altered gut microbiota is sufficient to affect neurological and psychological symptoms in various mouse models. However, the mechanisms mediating gut-brain interactions remain poorly defined. Deeper understanding of the molecular communication between gut microbes and the central nervous system will uncover critical features of behavioral, psychiatric, and neurodegenerative diseases. Decoding the chemical messages between gut microbes and the host is the foundation of the research program of the Needham lab.

Graduate of Hebrew University Medical School in Jerusalem. Israel Residency in Pediatrics and adult neurology in Israel Residency in pediatric neurology at the Johns Hopkins Hospital, Baltimore USA, and consultant in neurology for the human genetic Moore clinic (head: VA \.McKusick ) Israeli board certification: Pediatrics; Neurology; Pediatric Neurology; Developmental medicine Former chairman of : Neurology, Meir Medical Ctr, Israel; The section of neurology, Tel-Aviv university; The ethical committee, Tel-Aviv University; The Israel society for pediatric neurology; The Israel society of adult neurology; The Israeli board of examiners in neurology Present: Professor (emeritus), the Sackler Faculty of Medicine, Tel-Aviv University; Chairman of neurology and the local review board, Mayne Hayeshua Med Ctr; The Israel Society for Clinical Neurophysiology Author of about 300 scientific papers and 10 book chapters Member of editorial board: Brain & Development; Int. J of Neurosurgery, J Pediatric Neurology (Turkey), Current Drug Therapy, Associated editor: Frontiers in Neurology, Frontiers in Psychiatry Reviewer of > 20 medical journals Main interests and research: Neurogenetics; Autonomic nervous system; neuromuscular disorders; epilepsy; Attention Deficit Disorder; Sleep

Maya Koronyo-Hamaoui is a Professor of Neurosurgery, Neurology, and Biomedical Sciences at Cedars Sinai Medical Center in Los Angeles, CA, USA. After earning her M.Sc. and Ph.D. in Human Molecular Genetics and Psychiatric Genetics from Tel Aviv University School of Medicine in Israel, she completed a postdoctoral fellowship in neuroimmunology at the Weizmann Institute of Science. Prof. Koronyo-Hamaouis groundbreaking research focuses on the early detection and potential treatments for Alzheimers disease (AD). Her laboratory has explored the neuroprotective effects of immunomodulation approaches to clear toxic A-beta species, reduce neuroinflammation, and restore synaptic integrity and cognitive function. Additionally, she is internationally recognized as the first to discover the pathological hallmarks of AD, amyloid plaques, in the accessible retina. Her lab further developed a groundbreaking approach for the noninvasive detection of retinal amyloid deposits in living patients. Her innovative work in neuroimmunology, AD therapy, and retinal imaging technology has earned her numerous honors and awards. Maya Koronyo-Hamaoui Cedars-Sinai Medical Center USA

Susanna Rosi Background on your personal path Highlights of your past work Your present work at Altos and how it relates to our shared mission Why you have chosen to join Altos How you are leveraging the unique culture and scientific opportunities it provides What you hope to get out of the All Altos Retreat Born and raised under the Tuscan sun, as a neuroscientist and neuroimmunologist, I aim to understand how immune cells affect cognition in aging and disease. Across multiple injury paradigms and aging we demonstrated that 1) rejuvenating brain immune cells prevent cognitive deficits, 2) pharmacological inhibition of the integrated stress response reverses cognitive deficits. Our studies harness the power of immune modulation as both potential biomarkers and drivers of cognitive decline. Come and talk to me about…neuroinflammation, microglia, macrophages, innate immune system, cognition, brain injury, the Mars Mission, and being a mom of twins, everything Italian and sunflowers. Dr. Susanna Rosi is a founding Principal Investigator at Altos Labs and Professor in the Departments of Physical Therapy and Rehabilitation Science and Neurological Surgery at the University of California San Francisco. Formerly the Lewis and Ruth Cozen Chair Professor in the Departments of Physical Therapy Rehabilitation Science and Neurological Surgery at UCSF. She studies the mechanisms responsible for the cognitive dysfunctions observed in normal aging and after traumatic brain injury, therapeutic brain irradiation and galactic cosmic ray exposure. Her work provided the mechanistic evidence for the role of microglia in the development of cognitive deficits after brain injury in a sex dependent manner. She was the first to demonstrated that modulation of the Integrated Stress Response rescues cognitive deficits after brain trauma and rejuvenates old mice by alleviating memory deficits and restoring neuronal and immune dysfunctions. She has been the recipient of several NCI, NIA, NINDS awards, she is a NASA investigator and the recipient of the 2021 J.W. Osborne Award for “fundamental discovery on normal tissue radiation responses” from the Radiation Research Society. Science Susanna is a neuroscientist and neuroimmunologist; her overarching interest is to study the mechanisms responsible for the cognitive dysfunctions observed in the context of ageing, traumatic brain injuries, and neurodegenerative states. A major goal of the studies is to decipher the role of various brain cell types (neurons, astrocytes, microglial cells, glial cells) as well as peripheral immune cell responses to ageing, trauma, neurodegenerative diseases with the goal of understanding on a molecular and cellular level how long lasting cognitive defects can be reversed. Her work is focused on understanding how immune cells relate to cognitive outputs in the context of aging, traumatic brain injury, cancer therapy, and space radiation. Across multiple paradigms they have found that reprogramming of immune cell populations can reverse cognitive modalities (including learning, memory, social behaviors, risk taking phenotypes). These studies harness the power of immune modulation as both potential biomarkers and drivers of cognitive decline in multiple neurodegenerative states. The team is setting up a CRISPR-based genome-wide screening to understand microglia activation and identify novel therapeutic targets to treat neurocognitive dysfunctions. Susannas Team made the amazing discovery that long-lasting dementia after TBI and aging related cognitive dysfunction can be reversed by briefly inhibiting the integrated stress response (ISR) pharmacologically. The curing effects of this short treatment are long-lasting, suggesting that a mal-adaptive ISR is locked into a self-sustaining feedback loop that is the culprit of the cognitive defects. It is a major aim to find out how this loop is wired cellularly and molecularly. Contribution to Mission Susanna s work provides powerful proof of concept that age and injury related dysfunction can be fixed, even long after initiating events have occurred. Furthermore, the Susannas teams body of work further validates those common mechanisms (both ISR and immune) underlie multiple neurodegenerative states suggesting that single intervention strategies can target multiple disorders. Given that the intervention with the specific and well-understood ISR inhibitor ISRIB (and recently acquired Praxis compounds) selectively affects one of the cell stress networks, her work tangibly validates the general approach of modulating stress signaling networks for therapeutic benefit. In addition to contributing to the HR3 initiative, the teamwork is set to integrate in the ORCA project by studying reprogramming in different brain and immune cells as a means to rejuvenate the brain. Furthermore, the Rosi Team is collaborating with groups across the Altos network to explore new target pathways for reversing cognitive loss including investigation of trauma induced heterochromatin changes (SDI) brain metabolomic alterations (with the Nunnari, Erbay Groups), and cell-specific CRISPR screening. Translational Activities Susanna s Team is poised to engage with Altos IOM in preclinical studies clinical trials for multiple age-related diseases including traumatic brain injury, cancer therapy, Alzheimer s disease dementia, virus induced cognitive decline. The Rosi Teams studies relate molecular and cellular alterations to system- and organismal-wide changes. The teams expertise in rodent behavioral, cognitive, sensorimotor, and neuropathy models allows for an improved understanding of cellular and molecular pathways across multiple age reported maladaptive outcomes. This allows for rapid screening of intervention strategies (such as Praxis compounds, immune mediators) across multiple neurodegenerative diseases. Susanna s clinical connections (UCSF, University of Washington, University of Denver) will allow for screening mechanisms identified in preclinical studies in patient samples (brain and blood).

Gal Bitan, PhD Department of Neurology, University of California, Los Angeles (UCLA) Gal Bitan received his Ph.D. in organic chemistry from the Hebrew University in 1996. He went on to pursue postdoctoral studies on the structural biology of ligand receptor systems at Harvard Medical School Beth Israel-Deaconess Medical Center and continued to tackling the problem of protein misfolding and aggregation at Harvard Medical School Brigham and Women& 39 s Hospital. In 2004, Dr. Bitan joined the Department of Neurology in the David Geffen School of Medicine at UCLA where he is currently a Professor. His research program includes basic and translational research focused on the role of amyloidogenic proteins in neurodegenerative diseases. Dr. Bitan has published > 140 research papers, book chapters, and reviews. He has served on multiple NIH and VA study sections and as a member of the editorial boards of the Journal of Biological Chemistry, Frontiers in Molecular Neuroscience, Scientific Reports, Annals of Translational Medicine, and Biomolecules. He has mentored over 120 trainees and has received recognition for his mentorship at both the undergraduate and postdoctoral levels.

Jarred Griffin received his PhD from the Centre for Brain Research at the University of Auckland, New Zealand. His thesis investigated the development of an astrocyte-selective gene therapy vector to degrade chondroitin sulphate proteoglycans following spinal cord injury allowing for axon regeneration. He then used bipedal rehabilitative training to modulate neuroplasticity and further enhance functional recovery. Following his PhD, he joined the lab of Prof. Frank Brake at The German Center for Neurodegenerative Diseases where he continued his research of using rehabilitation as a combinatorial therapy after spinal cord injury. After recently receiving a German Research Foundation collaborative research grant, his research will expand how rehabilitation influences neuroplasticity and behavior and how it can be used in translational spinal cord injury studies.

Choti ma Bottcher is a research team leader of the Clinical Neuroimmunology group at the Experimental and Clinical Research Center (ECRC), Charite Universitatsmedizin Berlin, Germany. Dr. Böttcher obtained her PhD at Institute of Pharmacy, Faculty of Natural Sciences at Martin Luther University Halle Wittenberg, Halle Saale, Germany. In the first year of her postdocteral fellow, she continued her study on biosynthesis of mammalian morphine at Martin Luther University Halle Wittenberg and later at Donald Danforth Plant Science Center, MO, USA. In 2006, she moved to Charite Universitatsmedizin Berlin and has started her new research field systems immunology in neuroscience, with particular emphasis on myeloid cells including monocytes and brain microglia macrophages. Currently, her research aims to identify cellular and molecular complexity and heterogeneity of human myeloid cells in different body compartments including peripheral blood, cerebrospinal fluid, and the CNS and to further investigate how these features alter during neuroinflammation. In her group, high dimensional singlecell immune profiling techniques such as mass cytometry (cytometry by time of flight, CyTOF) and imaging CyTOF has been established for an investigation of phenotypic profiles of circulating myeloid cells in the peripheral blood and the cerebrospinal fluid, as well as for immune phenotyping of tissue resident macrophages such as the CNS microglia and macrophages.

Audrey Lafrenaye is an Assistant Professor in the department of Anatomy and Neurobiology at Virginia Commonwealth University in Richmond VA, USA. Her background is in cellular and molecular neuroscience, with focuses on quantitative immuno histology, glial pathology (including microglia, astrocytes and oligodendrocyte), and central fluid percussion injury models to induce brain injury in both rats and pigs. The work in her laboratory focuses on evaluating the progression and molecular mechanisms involved in diffuse neuronal and glial pathologies following traumatic brain injury.

Dr. Sungchil Yang achieved PhD in the department of molecular and integrative physiology, University of Illinois at Urbana & Champaign, studying a biophysical role of individual auditory neurons from cochlear nucleus to auditory cortex in auditory information processing under the supervision of Dr Albert S. Feng. Then, Dr Yang joined Helen Wills Neuroscience Institute of University of California at Berkeley as a postdoctoral fellow, studying mechanisms of an auditory phantom pain, tinnitus, with Dr Shaowen Bao. His research regarding the sensory system continued in Center for Integrative Neuroscience of University of California at San Francisco as a research associate, studying a role of axon initial segment of auditory neurons in information processing and a cellular basis of perceptual learning with Dr Kevin J. Bender and Christoph E. Schreiner, respectively. Then, he joined the Department of Neuroscience in City University of Hong Kong.

Fadel Tissir graduated in Biology from University Sidi Mohammed ben Abdellah, Fes, Morocco and earned his MSc degree from Liege University and PhD from the Free University of Brussels, Belgium. He worked as a postdoc on genetic factors predisposing to psychiatric disorders at the University of Antwerp from 1998 to 2000. He moved medical University of Louvain in 2001 as senior post doc. He was appointed as Assistant Professor in 2005 and promoted to the rank of Associate professor in 2008 and full Professor in 2018. In parallel to his academic career, Fadel Tissir was appointed as Research Associate at the Belgian Funds for Scientific Research in 2005 and promoted to the rank of Senior Research associate in 2013 and Research Director in 2017. His research focusses on the cellular and molecular mechanisms implicated in development and diseases of the nervous system. He has been active in the field of developmental neuroscience for more 20 years with emphasis on the role of planar cell polarity PCP and cytoskeletal proteins. his team discovered core component of PCP signaling and engineered mutant mouse models for all PCP genes. This program was very successful and led to the identification of a fascinating and unanticipated link between the mechanisms that regulate epithelial PCP on the one hand and those underlying numerous neurodevelopmental processes one the other hand. Hismoved the field of PCP from a purely observational phenomenon related to the stereotypic organization of hairs and sensory bristles in insects to concepts that govern the early blueprint of the mammalian nervous system wiring. This paved the way to important developments in the fields of neurogenesis, neuronal migration, wiring of the nervous system and ependymal ciliogenesis. This series of original findings were published in high impact journals Tissir et al. Nature Neuroscience 2005, Zhou et al. Science 2008, Tissir et al. Nature Neuroscience 2010, Boutin et al. PNAS 2014, Qu et al. PNAS 2014 Chai et al., Nature Neuroscience 2014 Wang et al. Nature Communications 2016 Damiani et al. Nature Communications 2016, Aragona et al Nature 2020

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Dr. Pignatelli received his Ph.D. in molecular biology in 2007 from Universidad Autonoma de Madrid (Madrid, Spain). After different postdoctoral periods in different laboratories, he joined Ignacio Torres Aleman Laboratory in the Cajal Institute, working in neuroendocrinology and mood states. Nowadays, he got a postdoctoral position at the Cajal Institute where he combines his research work about brain communication to peripheral systems for homeostasis and well-being, with his work as scientific responsible for an NGS facility in the Cajal Institute-CSIC.

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PROF. DR. CHRISTIAN SCHACHTRUP Im Winkel 2 79232 March E-mail: [email protected] Born 21st December 1973 in Münster Married, 2 Children (*31.1.2013, *29.2.2016) PROFESSIONAL EXPERIENCE 12/2017 – today Heisenberg Professor (tenured) Institute of Anatomy and Cell Biology, Albert-Ludwigs-Universität Freiburg Germany 07 2010122017 Research Group Leader Institute of Anatomy and Cell Biology, Albert-Ludwigs-Universität Freiburg, Germany Basic research in Neuroscience Neuronal regeneration at the neurovascular interface ï‚· Personnel and budget responsibilities University-level teaching duties: Teaching activities in Human Medicine and Molecular Medicine (Anatomy); Bachelor's and Master's courses in Biology 05/2008-05/2010 Postdoctoral Scientist Research group: Prof. Katerina Akassoglou; Gladstone Institute of Neurological Disease, University of California, San Francisco, USA Topic: „Molecular mechanisms of fibrin functions at the neurovascular unit“. 01/2005-04/2008 Postdoctoral Scientist Research group: Prof. Katerina Akassoglou; Department of Pharmacology, University of California, San Diego, USA Topic: „Molecular mechanisms of fibrin functions at the neurovascular unit“. 01/2004-09/2004 Visiting Scientist Research group: Prof. Hisatake Kondo; Department of Histology, Tohoku University, Sendai, Japan Topic: „Functional Analysis of fatty acid binding proteins in the immune response of brain microglia“. Curriculum Vitae Prof. Dr. Christian Schachtrup 01/2000-10/2003 Graduate Research Student Research group: Prof. Friedrich Spener; Institute of Biochemistry, Westfälische Wilhelms-Universität Münster, Germany Topic: „Functional analysis of fatty acid binding proteins of the lung with the the aid of inflammation and knockout approaches EDUCATION AND DEGREES 22.10.2003 Dr. rer. nat. (magna cum laude) 30.09.1999 Diploma Degree in Biology (very good) 1994-1999 Biology Studies - Major in Biochemistry Westfalische Wilhelms Universitat Munster Germany FELLOWSHIPS AND AWARDS 2017 Heisenberg Professor "Professor for Anatomy with a focus on experimental neuroregeneration”. Positive evaluation received in 2020. 2016 (granted) Heisenberg-Programme "Molecular mechanisms of neural stem cell differentiation in central nervous system disease with blood-brain barrier opening 2010 J. David Gladstone Institutes 2010 Postdoctoral Award of Excellence in Science. Gladstone Institute of Neurological Disease, University of California, San Francisco, USA. 2005-2007 DFG postdoctoral fellowship, Research Topic: „Molecular mechanisms of fibrin functions at the neurovascular unit“. 2004 DFG guest researcher fellowship Research Topic: „Functional Analysis of fatty acid binding proteins in the the immune response of brain microglia“. 2002 Unilever Stiftungsfond scholarship Research Topic: „Functional analysis of fatty acid binding proteins of the lung with the aid of inflammation and knock-out approaches“. REVIEWER ACTIVITIES Scientific journals: Glia – Arteriosclerosis, Thrombosis, and Vascular Biology – Biomolecules – Cell and Tissue Research – Cellular and Molecular Life Sciences – Acta Biomaterialia – Journal of Anatomy – Neurogenesis – Neuroscience – Molecular Neurobiology – Scientific Reports – Bioscience Reports – Biology Curriculum Vitae Prof. Dr. Christian Schachtrup Communications – Nature Cell Biology – Experimental Cell Research – Neuronal Regeneration Research – JOVE Funding agencies: Deutsche Forschungsgemeinschaft, Germany (DFG), Intra-CREATE (Singapore), The Dutch Research Council (NWO). PROFESSIONAL QUALIFICATIONS 2022 Fachanatom Anerkennung durch die Anatomische Gesellschaft 2021 Guest Editor of the Cell & Tissue Research Special Issue entitled Modulating Scar Formation For Improving Brain Repair From Coagulation & Inflammation to Cell Therapy”. 2019 Organizer of the International Freiburg Symposium MODULATING SCAR FORMATION FOR IMPROVING BRAIN REPAIR: FROM COAGULATION & INFLAMMATION TO CELL THERAPY". 2017 Praparieren für Anatomen Universitat Tubingen 2013 today Organisation of the Annual Retreat of the Institute of Anatomy and Cell Biology 2014-today Approved examiner of the Faculty of Medicine, University of Freiburg 2012 Certificate in University level teaching (Medizindidaktische Qualifikation I, Block 1 und 260 AE 2010 today Responsible project leader for animal experiments 2010 today Responsible project leader for working with genetically modified organisms 2003 Certificate for working with genetically modified organisms („Sicherheitsmaßnahmen und Arbeitsschutz bei gentechnischen Arbeiten“) SOCIETY MEMBERSHIPS Anatomische Gesellschaft Society For Neuroscience SFN Deutsche Multiple Sklerose Gesellschaft dmsg Verband Biologie, Biowissenschaften und Biomedizin in Deutschland VBIO Curriculum Vitae Prof. Dr. Christian Schachtrup SELECTED ORAL PRESENTATIONS Mechanisms of NSC differentiation: from Coagulation to Immunomodulation. Cambridge Centre for Myelin Repair Seminar Series. 30th June 2022. Invited Talk. Fibrinogen–induced BMP signaling modifying stem cell behavior in CNS disease. 13th BMP conference, virtual BMP forum. 28th July 2021. Invited Talk. Einfluss der Störung der Blut-Hirn-Schranke und von Fibrinogen auf neurale Stammzellen. 93. Kongress der Deutschen Gesellschaft für Neurologie (DGN). Berlin, Germany 2020. Symposium: Das Endothel im Fokus bei Gefäßplastizität und pathologischer Neovaskularisation. Invited Talk. Fibrinogen deposition in the subventricular zone stem cell niche induces neural stem cell differentiation into astrocytes via BMP receptor signaling. Anatomische Gesellschaft 114th Annual Meeting. Würzburg, September 25-27, 2019. Selected from Abstract. Modulating Scar Formation For Improving Brain Repair: From Coagulation & Inflammation To Cell Therapy. 1 st Freiburg Work Meeting 9th September 2019. Organizer Mechanisms of Neural Stem Cell differentiation in CNS disease with BBB opening. Institute of Analytical Chemistry, University of Regensburg, 2018. Invited Talk. Nuclear pore complex remodeling by p75NTR cleavage controls TGF-β signaling and astrocyte functions. Anatomische Gesellschaft 110th Annual Meeting. Würzburg, September 24, 2015. Selected from Abstract. The vascular-derived blood protein fibrinogen regulates the differentiation of adult neural stem cells into astrocytes after traumatic brain injury. 36th Annual Meeting of the German Society for Microcirculation and Vascular Biology (GfMVB). Münster, Germany, September 30 - October 02, 2014. Selected from Abstract The balance of Id3 and E47 determines BMP-induced adult neural stem cell differentiation into astrocytes after vascular damage. Anatomische Gesellschaft 109th Annual Meeting. Salzburg, Austria September 25, 2014. Selected from Abstract. Fibrinogen regulates the differentiation of adult neural stem cells into astrocytes after vascular damage. The Plasminogen Activation & Extracellular Proteolysis Gordon Research The conference, Ventura, USA, February 09-14 2014. Selected from Abstract. Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-β after vascular damage. 27. Jahrestagung der Anatomischen Gesellschaft, Würzburg, Germany September 30, 2010. Selected from Abstract. Fibrinogen mechanisms and functions in nervous system repair. Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, USA, 2010. Ceremony lecture for the 2010 Postdoctoral Fellow Award. Fibrinogen mechanisms and functions in nervous system repair. Institute for Anatomy and Cell Biology, Department of Molecular Embryology, University of Freiburg, Freiburg, Germany January 22, 2010. Invited Seminar. Fibrinogen mechanisms and functions in nervous system repair. UCSF Neuroscience Graduate Program Scientific Retreat, Asilomar, CA, September 2009. Invited Seminar. Identification of fibrin as a novel inhibitor of neurite outgrowth: Implications in spinal cord injury. 36th Society for Neuroscience (SfN) Annual Meeting, Atlanta, USA, October 14-18 2006. Selected from Abstract. Fibrin deposition and axonal damage in spinal cord injury. 18th International Congress on Fibrinolysis and Proteolysis, San Diego, USA, August 27-31 2006. Selected from Abstract. Curriculum Vitae Prof. Dr. Christian Schachtrup BIBLIOGRAPHY 10 MOST IMPORTANT PUBLICATIONS 1. Conforti P, Mezey S, Nath S, Chu YH, Malik SC, Martínez Santamaría JC, Deshpande SS, Pous L, Zieger B, Schachtrup C. Fibrinogen Regulates Astrocyte Scar Border Formation after Vascular Damage. Glia, DOI: 10.1002/glia.24166. IF: 7,45 2. Malik SC, Sozmen E, Baeza-Raja B, Le Moan N, Akassoglou K, Schachtrup C. In vivo functions of p75NTR: challenges and opportunities for an emerging therapeutic target. Trends Pharmacol Sci, Review, 2021, 42:43. IF: 13,50 3. Pous L, Deshpande SS, Nath S, Mezey S, Malik SC, Schildge S, Bohrer C, Topp K, Pfeifer D, Fernández-Klett F, Doostkam S, Galanakis DK, Taylor V, Akassoglou K, Schachtrup C. Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling. Nat Commun. 2020, 11:630. IF: 12,12 4. Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K. 2017. Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Neuron. 96:1003-1012. IF: 14,02 5. Pfurr S, Chu YH, Bohrer C, Greulich F, Beattie R, Mammadzada K, Hils M, Arnold SJ, Taylor V, Schachtrup K, Uhlenhaut NH, Schachtrup C. 2017. The E2A splice variant E47 regulates the differentiation of projection neurons via p57(KIP2) during cortical development. Development. 144:3917-3931. IF: 6,1 6. Bohrer C, Pfurr S, Mammadzada K, Schildge S, Plappert L, Hils M, Pous L, Rauch K, Dumit V, Pfeifer D, Dengjel J, Kirsch M, Schachtrup K, Schachtrup C. 2015. The balance of Id3 and E47 determines neural stem/precursor cell differentiation into astrocytes. EMBO J, 34:2804-19. IF: 10,75 7. Schachtrup C, Ryu JK, Mammadzada K, Khan AS, Carlton PM, Perez A, Christian F, Le Moan N, Perez A, Vagena E, Baeza-Raja B, Rafalski V, Chan JP, Nitschke R, Houslay MD, Ellisman MH, Wyss-Coray T, Palop JJ, Akassoglou K. 2015. Nuclear pore complex remodeling by the cleaved p75 neurotrophin receptor regulates TGF-beta signaling and astrocyte scar formation. Nat Neurosci, 18:1077-80. IF: 14,98 8. Schachtrup C, Ryu JK, Helmrick M, Vagena E, Galanakis DK, Degen JL, Margolis RU, Akassoglou K. 2010. Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-β after vascular damage. J Neurosci 30:5843-5854. IF: 5.97 9. Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson R, Haddad GG, Karin M. 2008. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature 453:807-811. IF: 44.958 10. Schachtrup C, Lu P, Jones LL, Lee JK, Lu J, Sachs BD, Zheng B, Akassoglou K. 2007. Fibrinogen inhibits neurite outgrowth via beta3 integrin-mediated phosphorylation of the EGF receptor. Proc Natl Acad Sci USA 104:11814-11819. IF: 9,81 Freiburg, 19.08.2022 Prof. Christian Schachtrup

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Mai-Lan Ho, MD, is an Associate Professor of Radiology at Nationwide Childrens Hospital and The Ohio State University, where she has served as Director of Radiology Research, Director of the Translational Neuroimaging Core, Director of the Advanced Neuroimaging Core, Faculty Lead of the Imaging Genomics Research Affinity Group, Chair of the Asian Pacific American Network, and Secretary of the Association for Staff and Faculty Women. She is a physician-scientist who specializes in translational advanced MRI, head & neck imaging, and neurogenomics. Dr. Ho is lead author of the textbook Neuroradiology Signs; editor of The AAWR Pocket Mentor and Pediatric Neuroimaging: State-of-the-Art and engages broadly in diversity, inclusion, and global outreach initiatives.

Dr. El Hadji Seydou Mbaye was born in 1978 in Kaolack a region of Senegal. During 2008-2013, he earned his Ph.D. in Biology and Human Pathologies with the collaboration of the International Agency for Research on Cancer World Health Organization, (IARC/WHO), Lyon (France)He obtained a Masters of Life and Health, Specialty Biology of microorganisms, Virology a Masters of Life and Health, option Immuno-physiopathology a License of Biochemistry in Louis Pasteur University of Strasbourg (France); and a General Degree in Sciences and Technologies in University of METZ (France). He was certified Grade 10/10 by the Federation International of Gynecology Obstetric (FIGO), the Accreditation Council of Oncology in Europe (ACOE), and the Institute Catalan of Oncology (ICO). These credits were recognized for Physicians Recognition Award (AMA PRA Category 1) by the American Medical Association. He was awarded the international Outstanding Scientist Awards 2020, Awarded as the Best Researcher Award 2021, by VDGOOD. He was certified, by the United Nations, by IARC/WHO. He has published 1 Book with a style of philosophical story. Author of the World Program against Cancer in Low and Middle Incomes Countries, he is the lead author of more than 90 peer-reviewed research articles published in reputed journals. Dr. Mbaye is Editor-in-Chief of 4 journals and an Editorial Board Member of 157 International Journals, and then he has Edited and Reviewed 270 peer-reviewed articles. He is a member of the Allied Academies, member of the World Society for Virology (WSV), member of Worlds Leading Virologists Group: Facing Covid-19, member of the U.S. National Academies of Sciences, Engineering, and Medicine (NASEM) Societal Experts Action Network (SEAN), and also, member of BCNet International Working Group, IARC WHO.Dr. MBAYE has formed for free, more than 250 Healthcare Professionals for the techniques of cervical cancer screening in Senegal. He has screened for free more than 2000 women for cervical cancer in Senegal. He appeared on local media, 2S TV, Leeral.net, Mbour TV, Sen TV, and 7TV

Ljudmila Stojanovich received her Ph.D. in Medicine, with the thesis Neuropsychiatric manifestations in patients with Systemic Lupus Erythematosus in 1999. Dr. Stojanovichs research focuses on Systemic Lupus Erythematosus, Antiphospholipid Syndrome, and Vaccination in patients with Autoimmune Rheumatic diseases. She is an author of three monographs and of about 250 articles on various aspects of Autoimmune Rheumatic disorders, published in international and domestic journals and in conference proceedings. She is in Editorial Boards (Editorial Boards LUPUS LONDON. Reviewer in the CURRENT CONTENSTS or Science citation index like LUPUS REVIEWER DATABASE, Cellular and Molecular Neurobiology, The Journal of Rheumatology, Allergologia et Immunopathologia, and others. Prof Stojanovich is Associate Editor for Frontiers in Medicine, section: Rheumatology, and the Editor in Hindawi: Publishing Open Access research journals papers. She is a member of a number International projects, like the European Forum on Antiphospholipid Antibodies and Multicenter studies antiphospholipid antibodies, infections and autoimmune diseases She is a mentorSupervisor ships a numbers of post-doc students. She was in Invited Speaker for many lectures in Congresses and Symposia; organizer and Chairman of many Workshops, Seminars, and Symposia a member of the Steering Committee of the EULAR recommendations for vaccination in patients with auto-immune inflammatory rheumatic diseases (AIIRD)”, and the member of Steering Committee of the “EULAR recommendations for the prevention and management of adult antiphospholipid syndrome member of European Lupus Society. Professor Stojanovic is EULAR Honorary Member, and The Member of “The International Team of Medical Experts for the Topic on antiphospholipid syndrome (Hughes Sy) and systemic lupus INTERNATIONAL CHARITY The London Lupus Centre), she was the Chairman in the International Congress Antiphospholipid syndrome Hughes syndrome importance of multidisciplinary approaches- 30 years since definition 2013 GRANT 2015 of the EUROPEAN STROKE CONFERENCE for excellent research in cerebrovascular diseases reviewed by the Scientific and programmer Committees”, and presented at the 24th Annual Meeting; Vienna, May 2015. Member of ILLUMINATE steering committee: the phase 3 lupus ILLUMINATES clinical trials of TabalumabEli Lilly and Company, MD, Ph.D. FRCP are willing to serve as a consultant to Lilly Research Laboratories, a division of Eli Lilly and Company Lilly in connection with the development of Tabalumab also known as LY2439821. Co-Chairman and the lector LUPUS ACADEMY EASTERN EUROPEAN ROADSHOW of EULAR Belgrade, Member of the American Association for the Advancement of Science from 2017 The Member of the international team of medical experts for the topic on APS Hughes Sy Chairman in the International Congress 12th the European Forum on Antiphospholipid Antibodies in Belgrade, Serbia, on March 25th, 2021 Professor Ljudmila Stojanovichs Impact Point is 300.14, and the number of citations is more than 3720. Research Interests: SYSTEMIC LUPUS ERYTHEMATOSUS ANTIPHOSPHOLIPID SYNDROME VACCINATION IN PATIENTS WITH AUTO-IMMUNE INFLAMMATORY RHEUMATIC DISEASES Title Full Research Prof Ljudmila Stojanovich, MD PhD Internal medicine rheumatologist Belgrade University Serbia

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A consultant Neurosurgeon with the Federal Medical Center, Abeokuta Nigeria, and the head of the neurosurgery unit of the hospital. A 2007 medical graduate of the Ladoke Akintola University of Technology (LAUTECH) College of Health Sciences, Nigeria Boarded certified in Neurosurgery by the West African College of Surgeons and the National Postgraduate Medical College of Nigeria. Research interest include myelomeningocele, traumatic brain injury, intracranial infections, and brain tumors.

Dr. Huile Gao received his PhD in Pharmaceutics from School of Pharmacy, Fudan University in 2013. Then he joined the West China School of Pharmacy, Sichuan University. Dr. Gao s research interests focus on the design, synthesis, characterization and evaluation of stimuli responsive nano materials for drug delivery to improve tumor and brain diseases treatment. He is the highly cited scientist Clarivate Analytics 2020 highly cited Chinese researcher Scopus and has published over 150 peer-reviewed articles with an H-index of 56. He served as editor of the books neurotoxicity of nano materials and nano medicines and Brain Targeted Drug Delivery Systems. He is now serving as Editorial Board Member of Acta Pharma ceutica Sinica B, Expert Opinion on Drug Delivery, International Journal of Pharmaceutics, Chinese Chemical Letters, Pharmaceutics, Current Drug Metabolism, etc.

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Alexandrina Nikova is a neurosurgical trainee at Evaggelismos General Hospital in Athens, Greece .She graduated in 2018 the Democritus university of Thrace. Since then she is a two -time winner of an international research award and author of one book. Alexandrina Nikova is a last year student at Democritus University of Thrace, Alexadnroupolis, Greece. She is also a member of the neurosurgical lab faculty of the university and assistant in the operations for 2,5 years. She was a volunteer in the neurological department (Montana, Bulgaria 2016) and a hospitalization guest at the department of neurosurgery (Zurich, Switzerland 2017). Currently she is chosen to be a mentor of Fundamental neuroscience for neuroimaging of Johns Hopkins. Her recent researches include the field of neuro-oncology, neurosurgery, traumatic brain injuries, forensic science, vascular neurosurgery and pediatric neurosurgery.

Brandon Lucke Wold was born and raised in Colorado Springs, CO. He graduated magna cum laude with a BS in Neuroscience and distinction in honors from Baylor University. He completed his MD/PhD Masters in Clinical and Translational Research, and the Global Health Track at West Virginia University School of Medicine. His research focus was on traumatic brain injury, neurosurgical simulation, and stroke. At West Virginia University, he also served as a health coach for the Diabetes Prevention and Management program in Morgantown and Charleston, WV, which significantly improved health outcomes for participants. In addition to his research and public health projects, he is a co-founder of the biotechnology company Wright-Wold Scientific, the pharmaceutical company CTE cure, and was a science advocate on Capitol Hill through the Washington Fellows program. He has also served as president of the WVU chapters for the American Association of Pharmaceutical Scientists, Neurosurgery Interest group, and Erlenmeyer Initiative Entrepreneur group. In addition, he has served as vice president for the graduate student neuroscience interest group, Nu Rho Psi Honor Society, and medical students for global health. He was an active member of the Gold Humanism Honor Society and Alpha Omega Alpha Honor Society. He is currently a member of the UF House Staff Council, Positive Culture Committee, Quality Improvement Committee, Board of Directors Alachua County Medical Society, and Accreditation Requirements Review Committee. He is married to Noelle Lucke-Wold and has two children. As a family, they enjoy running with their dogs, rock climbing, and traveling. In his spare time, Brandon frequently runs half marathons and 10ks together with is wife. Brandon also enjoys reading, playing piano, discussing philosophy, and playing chess. He is currently a Pgy5 neurosurgery resident at University of Florida pursuing endovascular enfolded training and was awarded the Dempsey Cerebrovascular Research Fellowship.

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Dr. Uqbah Iqbal is a Socioeconomic Researcher at Research for Social Advancement. Winning Second Place in Malaysian Historical Essay Writing Competition 2013, he was the recipient of Research University Fellowship Scheme, Graduate on Time Award and Outstanding Student Award from Faculty of Social Sciences and Humanities as well as the Youngest Ph.D. in History Holder and the only Malaysian achieved a Ph.D. in History in conjunction with the 43rd Convocation of Universiti Kebangsaan Malaysia. He's authoring notable books/ebooks such as The Historical Development of the Malay Nationalism Before Independence, The Historical Development of the Malay Society Economic Nature During Pre-Colonial Era, The Historical Development of British Investment in Malaya Before the Second World War, The Historical Development of Foreign Investment in the Formation of the Malaysian Economy and Sejarah Pemikiran Pandang Ke Timur: Kepentingan Jepun Dalam Pembangunan Sosio-Ekonomi Malaysia (1906-1980). His publications have appeared in a wide range of international and national journals such as TAWARIKH, SUSURGALUR, Management and Administrative Sciences Review, Social and Basic Sciences Research Review, Jurnal Kemanusiaan, Jurnal Sejarah, Jurnal Pengajian Melayu, Jebat, International Journal of Social Science and Humanities Research, Asia Pacific Journal of Education, Arts and Sciences, Asian Social Science and Geografia. He's also actively in the editorial board such as Asian Social Science, International Journal of Art and Literature, International Journal of Archaeology and History, American Journal of Social Sciences, Asia Pacific Journal of Education, Arts and Sciences, Social Sciences, Humanities and Social Sciences, History Research and Pratidhwani the Echo. Through his involvement as a reviewer with the Nonfiction Authors Association, 15 of his reviewed books received Awards.

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